Taylor and Patrick co-authored a commentary on recent progress in engineering cell therapies for cancer, including perspectives on exciting recent innovations in this space. Read more here.
This collaboration with the Nguyen and Schatz labs decribes the development of highly stable and stimuli/pH-responsive ultra-small polymer-grafted nanobins (usPGNs) as candidate nano-scale drug delivery vehicles. Read more here.
This chapter was published as part of an issue of Methods in Molecular Biology dedicated to the study and therapeutic use of Extracellular RNA. Read more here.
This study, published in Protein Engineering, Design, and Selection, reports the BERDI method for engineering novel metabolite-responsive biosensors, for applications ranging from metabolic engineering to fundamental research. Read more here.
This review discusses both recent advances and emerging general principles for using mammalian synthetic biology to build cell-based therapies that are safe and effective. Read more here.
This chapter summarizes key strategies and challenges associated with studying and harnessing EV-mediated transfer for therapeutic applications, while providing contemporary perspectives on how choices of systems design and analysis method may impact the efficacy of EV-based therapies and the interpretation of EV-based investigations. Read more here.
This paper marks the first demonstration that MESA receptors can be multiplexed to function orthogonally in a single cell. We also report here, for the first time, a quantitative model for evaluating and ultimately designing new MESA receptors and new MESA-based technologies. Read more here.
Congrats to Devin! Read more here.
Synthetic biology: Sensing with modular receptors
Matthew Brenner, Jang Hwan Cho and Wilson W Wong
Sensing and responding to diverse extracellular signals is a crucial aspect of cellular decision-making that is currently lacking in the synthetic biology toolkit. The development of modular receptor platforms allows for the rewiring of cellular input-output relationships.