This chapter summarizes key strategies and challenges associated with studying and harnessing EV-mediated transfer for therapeutic applications, while providing contemporary perspectives on how choices of systems design and analysis method may impact the efficacy of EV-based therapies and the interpretation of EV-based investigations. Read more here.
This paper marks the first demonstration that MESA receptors can be multiplexed to function orthogonally in a single cell. We also report here, for the first time, a quantitative model for evaluating and ultimately designing new MESA receptors and new MESA-based technologies. Read more here.
Congrats to Devin! Read more here.
Synthetic biology: Sensing with modular receptors
Matthew Brenner, Jang Hwan Cho and Wilson W Wong
Sensing and responding to diverse extracellular signals is a crucial aspect of cellular decision-making that is currently lacking in the synthetic biology toolkit. The development of modular receptor platforms allows for the rewiring of cellular input-output relationships.
Image by Joshua Leonard and Kelly Schwarz, Northwestern University. Cell image by NIAID/NIH, used and modified under Creative Commons 2.0 license.
Congrats to Kelly, Nickey, and Taylor, whose paper was published today in Nature Chemical Biology! This paper is currently spotlighted on the homepage of NCB: http://www.nature.com/nchembio/index.html